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How Omicron Symptoms Differ From Delta, Past COVID-19 Variants: Charts (businessinsider.com)

Aria Bendix and Shayanne Gal 

10 hours ago

 

• Almost as soon as Omicron started spreading, doctors noticed slight differences in their patients' symptoms relative to prior variants. Mild, cold like symptoms — such as sore throats, sneezing, and runny noses — were increasingly common. But former hallmarks of COVID-19 — such as fevers, coughs, and loss of taste or smell — had dwindled.
• "The most reported symptoms of Omicron are really very much like a cold, especially in people who've been vaccinated," Dr. Claire Steves, a scientist involved with the Zoe COVID Symptom Study, said in a recent video.
• The Zoe study uses a smartphone app to log how hundreds of thousands of people are feeling every day across the UK. It offers a comprehensive look at how COVID-19 symptoms have changed over the course of the pandemic — most notably, with the advent of the Delta and Omicron variants. 
• The following chart shows how Omicron symptoms compare to those of its predecessors, based on data collected by the Zoe app. 

Frequency of COVID-19 symptoms by variant

A table showing the frequency of different COVID-19 symptoms by variant.

SYMPTOM	OMICRON	DELTA	PRE-DELTA
Runny nose	Common	Common	Sometimes
Headache	Common	Common	Common
Fatigue	Common	Common	Common
Sneezing	Common	Sometimes	Rare
Sore throat	Common	Common	Sometimes
Persistent cough	Sometimes	Common	Common
Chills or shivers	Sometimes	Sometimes	Sometimes
Fever	Sometimes	Sometimes	Common
Loss of smell	Rare	Sometimes	Common
Chest pain	Rare	Rare	Rare
Shortness of breath	Rare	Sometimes	Sometimes

 

Runny nose, headache, fatigue, sneezing, and sore throat were the top five symptoms among people in the UK who recorded a positive COVID-19 test in the past few weeks. Meanwhile, 44% of people in that group reported a persistent cough, and 29% reported a fever. Loss of taste or smell was even less common, as the chart below shows

 

Omicron symptoms, from most to least common

A table showing Omicron symptoms, from most to least common.
 

SYMPTOM	FREQUENCY
Runny nose	73% 73%
Headache	68% 68%
Fatigue	64% 64%
Sneezing	60% 60%
Sore throat	60% 60%
Persistent cough	44% 44%
Hoarse voice	36% 36%
Chills or shivers	30% 30%
Fever	29% 29%
Dizziness	28% 28%
Brain fog	24% 24%
Muscle pains	23% 23%
Loss of smell	19% 19%
Chest pain	19% 19%

Note: Data is from January 5, 2022, based on people in the UK who tested positive for COVID-19 in the last few weeks (does not distinguish between vaccinated and unvaccinated).

Table: Shayanne Gal/Insider  Source: Zoe COVID Symptom Study

While the data doesn't distinguish between vaccinated and unvaccinated people, 70% of the UK population has had at least two vaccine doses as of Thursday.

Omicron cases often start with a sore throat, headache, and congestion

Dr. Jorge Moreno said he's seen an influx of COVID-19 cases lately at his outpatient clinic in Connecticut. Most of those patients were vaccinated, he said, so their symptoms tended to be milder and relatively short-lived. 

Many patients started out with a dry, scratchy throat that caused sharp pain when they swallowed.

"It's a very prominent symptom," said Moreno, an assistant professor of medicine at Yale School of Medicine. "It's not like a little tickle in the throat. If they're reporting it, they're saying that their throat feels raw." 

Sore throats were often coupled with sinus congestion and headache, he added, followed by a cough a day or so later. At a December news briefing, Ryan Noach, the CEO of Discovery Health, South Africa's largest private health insurer, said Omicron patients commonly reported a scratchy throat first, followed by nasal congestion, dry cough, and body aches.

"Cough is still part of the symptoms," Moreno said. He added, "It's not as bad as it was." Vaccinated people, he continued, "don't have those respiratory symptoms as much."

Loss of smell was also relatively rare among Omicron patients.

As of this month, less than 20% of people in the UK who recorded a positive COVID-19 test were logging the symptom into the Zoe app. Back in June, when the Delta variant was dominant in the UK, loss of smell was the sixth most common COVID-19 symptom among fully vaccinated people. In March, before Delta was detected and vaccines were widely available, 60% of UK adults ages 16 to 65 on the Zoe app reported loss of smell at some point in their illness. 

By contrast, fatigue became more pronounced among outpatients, who often reported feeling tired and achy, Moreno said.

"I've seen a lot more people reporting fatigue as one of their main symptoms," he said. "They're young people that typically can push through things. They need rest. They need to sleep. They're napping more."

Why are COVID-19 symptoms changing?

Scientists aren't sure why COVID-19 symptoms are changing.

Vaccines help reduce the severity of disease, but Omicron may be a less virulent virus on its own. Two recent lab studies, which haven't been peer-reviewed, suggested that Omicron could be less effective at attacking lung cells compared with prior variants. Another not-yet-peer-reviewed study, published on Wednesday, found that Omicron inherently reduced the risk of severe hospitalization or death from COVID-19 by 25% compared with Delta.

Omicron may also change the way the virus replicates or congregates in the body. A December study from the University of Hong Kong, which hasn't been peer-reviewed, found that Omicron replicated 70 times faster in the main airways, or bronchi, compared with Delta, but 10 times slower in the lung tissue. Another preprint study, released earlier this month, showed that the viral load from an Omicron infection peaked in saliva one to two days before it peaked in nasal swabs — a sign that Omicron may infect the throat before it infects the nose.

Still, doctors have noticed a clear gradient of symptoms based on a person's vaccination status.

"People that are unvaccinated go through a little bit of a longer and tougher course," Moreno said. "People that are vaccinated have a middle-of-the-way course. The boosted people, in many cases it's almost like an old cold: the sinus symptoms, the sore throat."

Before Omicron, Moreno said, his COVID-19 patients used to feel sick for about 10 to 14 days. Lately, he said, people who received a booster shot reported shorter bouts of illness than those who received fewer doses or none at all.

"Those individuals that are boosted, within five days, seven days of their onset of symptoms, their energy level comes back," he said. "Their symptoms are resolved."

Velandy Manohar, MD